Quantitative Pharmacology and Systems Modeling Lab
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Selected Publications

  • Cortés-Ríos, J., Ren, T., Hanan, N., Sher, A., Nader, A., Magee, M., Jusko, W.J., & Desikan, R. (2025). Hepatitis B in silico trials capture functional cure, indicate mechanistic pathways, and suggest prognostic biomarker signatures. Clinical Pharmacology & Therapeutics, 118(3), 600-612.

  • Cortés-Ríos, J. & Jusko, W.J. (2025). Insights into aldosterone regulation through pharmacokinetic-pharmacodynamic modeling of an aldosterone synthase inhibitor. Clinical Pharmacology & Therapeutics, 119(2), 414-426.

  • Cortés-Ríos, J., Sher, A., Magee, M., Jusko, W.J., & Desikan, R. (2025). A step-by-step workflow for performing in silico clinical trials with nonlinear mixed effect models. CPT: Pharmacometrics & Systems Pharmacology, 14(12), 1949-1964.

  • Cortés-Ríos, J., Rodriguez-Fernandez, M., Sorger, P.K., & Fröhlich, F. (2025). Dynamic modelling of cell cycle arrest through integrated single-cell and mathematical modelling approaches. PLOS Computational Biology, 21(10), e1012890.

  • Reyes, J.S., Cortés-Ríos, J., Fuentes-Lemus, E., Rodriguez-Fernandez, M., Davies, M.J., & López-Alarcón, C. (2024). Competitive oxidation of key pentose phosphate pathway enzymes modulates the fate of intermediates and NADPH production. Free Radical Biology and Medicine, S0891-5849.

  • Cortés-Ríos, J., Hermida, R.C., & Rodriguez-Fernandez, M. (2022). Dosing time optimization of antihypertensive medications by including the circadian rhythm in pharmacokinetic-pharmacodynamic models. PLOS Computational Biology, 18(11), e1010711.

  • Cortés-Ríos, J. & Rodriguez-Fernandez, M. (2021). Circadian rhythm of blood pressure of dipper and non-dipper patients with essential hypertension: a mathematical modeling approach. Frontiers in Physiology, 11, 1801.

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Quantitative Pharmacology and Systems Modeling Lab